Stress granule wikimili, the best wikipedia reader. Mammalian splicing factor sf1 interacts with surp domains of u2 snrnpassociated proteins. Surp and gpatch domaincontaining protein 1, rnabinding protein rbp, splicing factor 4. Both sf4 and sfrs14 contain 2 surp motifs and a single gpatch domain in their c termini. Sugp1 surp and gpatch domaincontaining protein 1 mus. In particular, many isoforms containing alternative exons are expressed in. Aggf1, angiogenic factor with g patch and fha domains 1. Alternatively spliced transcript variants have been described. Gene ontology go annotations related to this gene include nucleic acid binding and rna binding. The rna molecules stored are stalled translation preinitiation complexes.
Pdf mammalian splicing factor sf1 interacts with surp. Comprehensive transcriptomic analysis of the process of. Mammalian splicing factor sf1 interacts with surp domains of u2. Interacts with proteincoding genes, including 101f10. At1g04910 coatomer, beta subunit at3g15980 pectin lyaselike superfamily protein.
G patch domaincontaining protein 6,gpatc6,gpatch6,homo sapiens,human,kiaa1847,zc3h9,zc3hdc9,zgpat,zinc finger and g patch domaincontaining protein,zinc finger ccch domaincontaining protein 9,zinc f. Gabpa, ga binding protein transcription factor, alpha subunit 60kda. At3g52120 surp and gpatch domaincontaining protein 1. Unbound material was incubated for 1 h at 4c with protein g. Among its related pathways are mrna splicing major pathway.
Sampson and hewitt 2003 also cloned the mouse orthologs. This database of renal inner medullary collecting duct imcd proteins is based on published protein mass spectrometry data from the nhlbi epithelial systems biology laboratory. Sugp1 surp and gpatch domain containing 1, authors. Ezh2 is a polycomb group pcg protein that promotes the latestage development of cancer by silencing a specific set of genes, at least in part. With this, we aim to provide a visually compelling and complete overview of how micrornas relate to specific. Sugp1 surp and gpatch domain containing 1 is a protein coding gene. Two additional proteins containing surp domains were found by coip table 1, the u2 snrnpassociated surp motifcontaining protein u2surpsr140 and the a complex component surp and gpatch domaincontaining protein 1 sugp1sf4. As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. Gene alias uniprot accession ensembl id omim id description. Surp and gpatch domaincontaining protein 1like protein. Surp domains interact with sf1, and gpatch domains were shown to activate rna. Complete information for sugp1 gene protein coding, surp and gpatch domain containing 1, including. Putative splicing factor, arginineserinerich 14 is a protein that in humans is encoded by the.
Diseasecausing mutations in sf3b1 alter splicing by. We can not exclude the possibility that gpkow also binds dna in addition to rna since other gpatch domain containing proteins have been shown to be involved in dna repair and telomere. Gpatch domain and kow motifscontaining protein, gpkow. Rank locus id links locus select coexpressed genes description mutual rank weighted pcc wolf psort kegg pathway transcription factor gene symbol gene name msu id. Aliases sugp2, sfrs14, surp and gpatch domain containing 2, srfs14. Mammalian splicing factor sf1 interacts with surp domains. Sugp1 surp and gpatch domaincontaining protein 1 homo. In some of these proteins the g patch is the only recognisable domain but in most of them it is combined with other domains, which include welldefined rnabinding domains, such as the rrm, dsrbd, surp and r3h. Physiological substrates of campdependent protein kinase.
Sugp2 surp and gpatch domain containing 2 is a protein coding gene. We demonstrate that gpkow, which contains one gpatch domain and two kow motifs, is a nuclear rnabinding protein conserved between species. Loc1982691 surp and gpatch domaincontaining protein 1. The figure on the left represents the contact map with information on type of orientation two sses share color coded. Protein topology is represented by contact and orientation of secondary structure elements sses. Loom reads relevant scientific publications that mention human specific micrornas, extract the relevant parts, and then scores the relationship between the microrna and the specific gene or disease being studied. Loc1982691 surp and gpatch domaincontaining protein 1like wiretailed manakin gene id. Fumarylacetoacetate hydrolase domaincontaining protein 2a. Heat shock 70 kda protein 8 also known as heat shock cognate 71 kda protein or hsc70 or hsp73 is a heat shock protein that in humans is encoded by the hspa8 gene on chromosome 11. Sugp2 surp and gpatch domaincontaining protein 2 homo. Surp and gpatch domaincontaining protein 1, rna binding protein rbp, splicing factor 4. Gpkow is a rnabinding protein that binds rna in a pka regulated fashion.
Geneloc map region for chromosome 19 20,783,592 24,784,768 bp around gh19j022783 genes enhancers. Sugp2 ensg00000064607, surp and gpatch domain containing 2. Postset cysteinerich motif following a subset of set domains. Comprehensive transcriptomic analysis of the process of gonadal sex. Gtex compendium human tissue compendium novartis global cancer map broad institute nci60 cell lines national cancer institute. Hect and rld domain containing e3 ubiquitin protein ligase 2. Several groups of gpatch containing proteins are conserved in animals, plants and fungi. Among its related pathways are gene expression and mrna splicing major pathway. Pdf on jan 1, 2020, mat jusoh and others published ijhoscr. Atrich interactive domaincontaining protein 1a 3312 hspa8 heat shock cognate 71 kda protein 9919 sec16a 20 1. Ipr040169 surp and gpatch domaincontaining protein 12. An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by western blot with a specific polyclonal antibody or second epitope tag.
Genes upregulated in pc3 cells prostate cancer after knockdown of ezh2 geneid2146 by rnai. Protein annotations for g patch domaincontaining protein. Sf4 is a member of the surp family of splicing factors. Surp and gpatch domaincontaining protein 2, arginineserinerichsplicing factor 14, splicing factor, arginineserinerich 14. Below is a sorted list of the top 500 accessed transcripts since 722014. Only three common genes were found to be downregulated in all comparisons plectin domain containing protein, plec, tetratricopeptide. Sugp1, surp and gpatch domain containing 1 vertebrate orthologs 10 human ortholog sugp1, surp and gpatch domain containing 1. Atlas of genetics and cytogenetics in oncology and haematology home genes leukemias solid tumors cancerprone deep insight case reports journals portal teaching. Ezh2 is a polycomb group pcg protein that promotes the latestage development of cancer by silencing a specific set of genes, at least in part through trimethylation of. Stress granules are 100200 nm in size when biochemically purified, not surrounded by membrane, and associated with the endoplasmatic reticulum.
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